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Article

Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status.

Cancer - 1 Feb 2012

Sandulache Vlad C, Skinner Heath D, Ow Thomas J, Zhang Aijun, Xia Xuefeng, Luchak James M, Wong Lee-Jun C, Pickering Curtis R, Zhou Ge, Myers Jeffrey N

Abstract excerpt

BACKGROUND: Mutations in the tumor protein 53 (TP53) tumor suppressor gene are common in head and neck squamous cell carcinoma (HNSCC) and correlate with radioresistance. Currently, there are no clinically available therapeutic approaches targeting p53 in HNSCC. In this report, the authors propose a strategy that uses TP53 mutational status to individualize antimetabolic strategies for the potentiation of...

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Source

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Identifiers

PMID: 21720999
DOI: 10.1002/cncr.26321
PMCID: PMC3188683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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