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Article

The importance of Ile716 toward the mutagenicity of 8-Oxo-2'-deoxyguanosine with Bacillus fragment DNA polymerase.

DNA repair - 1 May 2020

Hamm Michelle L, Garcia Anarosa A, Gilbert Rachel, Johri Manavi, Ricart Miranda, Sholes Samantha L, Murray-Nerger Laura A, Wu Eugene Y

Abstract excerpt

8-oxo-2'-deoxyguanosine (OdG) is a prominent DNA lesion that can direct the incorporation of dCTP or dATP during replication. As the latter reaction can lead to mutation, the ratio of dCTP/dATP incorporation can significantly affect the mutagenic potential of OdG. Previous work with the A-family polymerase BF and seven analogues of OdG identified a major groove amino acid, Ile716, which likely influences the...

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PMID: 32113909
DOI: 10.1016/j.dnarep.2020.102826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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