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Article

A genome-wide multiphenotypic association analysis identified common candidate genes for subjective well-being, depressive symptoms and neuroticism.

Journal of psychiatric research - 1 May 2020

Chu Xiaomeng, Liu Li, Wen Yan, Li Ping, Cheng Bolun, Cheng Shiqiang, Zhang Lu, Mei Ma, Qi Xin, Liang Chujun, Ye Jing, Kafle Om Prakash, Wu Cuiyan, Wang Sen, Wang Xi, Ning Yujie, Zhang Feng

Abstract excerpt

Subjective well-being (SWB), depressive symptoms, and neuroticism are common and vital traits of mental disorders. Genetic mechanisms of SWB, depressive symptoms and neuroticism remain elusive now. The large-scale GWAS summary datasets of SWB (n = 229,883), depressive symptoms (n = 180,866), and neuroticism (n = 170,911) were obtained from published studies. MASH tool was applied to the GWAS datasets for...

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PMID: 32109668
DOI: 10.1016/j.jpsychires.2020.02.012

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