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Article

Whole exome sequencing identified six novel genes for depressive symptoms.

Molecular psychiatry - 1 May 2025

Li Ze-Yu, Fei Chen-Jie, Yin Rui-Ying, Kang Ju-Jiao, Ma Qing, He Xiao-Yu, Wu Xin-Rui, Zhao Yu-Jie, Zhang Wei, Liu Wei-Shi, Wu Bang-Sheng, Yang Liu, Zhu Ying, Feng Jian-Feng, Yu Jin-Tai, Cheng Wei

Abstract excerpt

Previous genome-wide association studies of depression have primarily focused on common variants, limiting our comprehensive understanding of the genetic architecture. In contrast, whole-exome sequencing can capture rare coding variants, helping to explore the phenotypic consequences of altering protein-coding genes. Here, we conducted a large-scale exome-wide association study on 296,199 participants from the UK...

Read the complete abstract on PubMed

Topics

Humans
Male
Female
Exome Sequencing
Genome-Wide Association Study
Depression

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Genetic Predisposition to Disease

Aged

Polymorphism, Single Nucleotide

Brain

Exome

United Kingdom

Source

Identifiers

PMID: 39472661
DOI: 10.1038/s41380-024-02804-1

Genes

TRIM27
UBD
ADGRB2
SVOP

Provenance

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