Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease.

Abstract excerpt

The accumulation of acquired mutations is an inevitable consequence of the aging process, but its pathophysiological relevance has remained largely unexplored beyond cancer. Most of these mutations have little or no functional consequences, but in a few rare instances, a mutation may arise that confers a competitive advantage to a stem cell, leading to its clonal expansion. When such a mutation occurs in...

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