Article
Unidirectional association of clonal hematopoiesis with atherosclerosis development.
Nature medicine - 1 Oct 2024
Díez-Díez Miriam, Ramos-Neble Beatriz L, de la Barrera Jorge, Silla-Castro J C, Quintas Ana, Vázquez Enrique, Rey-Martín M Ascensión, Izzi Benedetta, Sánchez-García Lucía, García-Lunar Inés, Mendieta Guiomar, Mass Virginia, Gómez-López Nuria, Espadas Cristina, González Gema, Quesada Antonio J, García-Álvarez Ana, Fernández-Ortiz Antonio, Lara-Pezzi Enrique, Dopazo Ana, Sánchez-Cabo Fátima, Ibáñez Borja, Andrés Vicente, Fuster Valentín, Fuster José J
Abstract excerpt
Clonal hematopoiesis, a condition in which acquired somatic mutations in hematopoietic stem cells lead to the outgrowth of a mutant hematopoietic clone, is associated with a higher risk of hematological cancer and a growing list of nonhematological disorders, most notably atherosclerosis and associated cardiovascular disease. However, whether accelerated atherosclerosis is a cause or a consequence of clonal...
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