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Article

Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease.

Circulation research - 2 Feb 2018

Fuster José J, Walsh Kenneth

Abstract excerpt

Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there may still be unidentified causal risk factors. Although the accumulation of somatic DNA mutations is a hallmark of aging, its relevance in cardiovascular disease or other age-related conditions has been, with the exception of...

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Identifiers

PMID: 29420212
DOI: 10.1161/CIRCRESAHA.117.312115
PMCID: PMC5826570

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