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Article

Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization.

Cancer causes & control : CCC - 1 Jun 2012

Matsuda Yasunori, Yamashita Satoshi, Lee Yi-Chia, Niwa Tohru, Yoshida Takeichi, Gyobu Ken, Igaki Hiroyasu, Kushima Ryoji, Lee Shigeru, Wu Ming-Shiang, Osugi Harushi, Suehiro Shigefumi, Ushijima Toshikazu

Abstract excerpt

BACKGROUND: Aberrant hypermethylation of specific genes is present in esophageal squamous cell carcinomas (ESCCs). Such hypermethylation is also present in normal-appearing esophageal mucosae of ESCC patients and is considered to contribute to the formation of a field for cancerization. On the other hand, the presence of global hypomethylation in ESCCs or in their background esophageal mucosae is unknown. METHOD:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22527164
DOI: 10.1007/s10552-012-9955-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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