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Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study

13 Oct 2021

Abstract excerpt

BACKGROUND: Plasma cell-free DNA (cfDNA) methylation has shown promising results in the early detection of multiple cancers recently. Here, we conducted a study to investigate the performance of cfDNA methylation in the early detection of esophageal cancer (ESCA). METHODS: Specific methylation markers for ESCA were identified and optimized based on esophageal tumor and paired adjacent tissues (n = 24)....

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PMID: 34641873
DOI: 10.1186/s12916-021-02109-y

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