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Article

Patterns and possible roles of LINE-1 methylation changes in smoke-exposed epithelia.

PloS one - 1 Jan 2012

Wangsri Siriporn, Subbalekha Keskanya, Kitkumthorn Nakarin, Mutirangura Apiwat

Abstract excerpt

Tobacco smoking and reduced methylation of long interspersed element-1 (LINE-1) are crucial in oral carcinogenesis. 5'UTR of human LINE-1 sequence contains several CpG dinucleotides which are methylated in various proportions (0-100%). Methylation levels of many LINE-1s in cancer were reduced, hypomethylated. The hypomethylation of each LINE-1 locus can promote instability of genome and repress expression of a...

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Identifiers

PMID: 23028911
DOI: 10.1371/journal.pone.0045292
PMCID: PMC3445447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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