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Article

A gene-based test of association through an orthogonal decomposition of genotype scores.

Human genetics - 1 Oct 2017

Chen Zhongxue, Wang Kai

Abstract excerpt

The burden test and the sequence kernel association test (SKAT) are two popular methods for detecting association with rare variants. Treated as two different sources of association information, they are adaptively combined to form an optimal SKAT (SKAT-O) method for optimal power. We show that the burden test is part of rather than independent of the SKAT. We introduce a new test statistic that is the sum of the...

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PMID: 28864915
DOI: 10.1007/s00439-017-1839-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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