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Article

Sequence kernel association tests for the combined effect of rare and common variants.

American journal of human genetics - 6 Jun 2013

Ionita-Laza Iuliana, Lee Seunggeun, Makarov Vlad, Buxbaum Joseph D, Lin Xihong

Abstract excerpt

Recent developments in sequencing technologies have made it possible to uncover both rare and common genetic variants. Genome-wide association studies (GWASs) can test for the effect of common variants, whereas sequence-based association studies can evaluate the cumulative effect of both rare and common variants on disease risk. Many groupwise association tests, including burden tests and variance-component...

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Identifiers

PMID: 23684009
DOI: 10.1016/j.ajhg.2013.04.015
PMCID: PMC3675243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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