Article
Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.
PLoS computational biology - 1 Nov 2017
Chen Yun-Ching, Gotea Valer, Margolin Gennady, Elnitski Laura
Abstract excerpt
Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We measured this relationship using principal component analyses and methylation-mutation associations applied at the nucleotide level and with respect to genome-wide...
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