Article
Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum.
PloS one - 1 Jan 2020
Nakanishi Hiroyoshi, Sawada Takeshi, Kaizaki Yasuharu, Ota Ryosuke, Suzuki Hiromu, Yamamoto Eiichiro, Aoki Hironori, Eizuka Makoto, Hasatani Kenkei, Takahashi Naoki, Inagaki Satoko, Ebi Masahide, Kato Hiroyuki, Kubota Eiji, Kataoka Hiromi, Takahashi Satoru, Tokino Takashi, Minamoto Toshinari, Sugai Tamotsu, Sasaki Yasushi
Abstract excerpt
Recent studies have shown that colorectal serrated lesions, which include sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs), are precursors of colorectal cancer. However, the molecular mechanisms underlying the carcinogenesis, particularly in TSAs, remain largely uncharacterized. To clarify their molecular and clinicopathological characteristics, we performed mutation and methylation...
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