Article
Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.
The Journal of pathology - 1 Jun 2016
Sekine Shigeki, Yamashita Satoshi, Tanabe Taro, Hashimoto Taiki, Yoshida Hiroshi, Taniguchi Hirokazu, Kojima Motohiro, Shinmura Kazuya, Saito Yutaka, Hiraoka Nobuyoshi, Ushijima Toshikazu, Ochiai Atsushi
Abstract excerpt
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional serrated adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 colorectal polyps, including hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous adenomas by using targeted next-generation...
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