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Article

WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps.

The American journal of surgical pathology - 1 Sept 2017

Hashimoto Taiki, Yamashita Satoshi, Yoshida Hiroshi, Taniguchi Hirokazu, Ushijima Toshikazu, Yamada Tesshi, Saito Yutaka, Ochiai Atsushi, Sekine Shigeki, Hiraoka Nobuyoshi

Abstract excerpt

Sessile serrated adenoma/polyps (SSA/Ps) are believed to be the major precursor of serrated pathway-derived colorectal carcinomas. To better characterize the process of progression from SSA/Ps to carcinomas, we analyzed 46 SSA/Ps with dysplasia and 45 SSA/Ps without dysplasia using targeted next-generation sequencing and immunohistochemistry. Among the WNT pathway genes analyzed, protein-truncating mutations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28614199
DOI: 10.1097/PAS.0000000000000877

Genes

MLH1
RNF43
APC
BRAF
CTNNB1
KRAS
MYC
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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