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Article

Clinicopathological and molecular correlations in traditional serrated adenoma.

Journal of gastroenterology - 1 Apr 2020

Sekine Shigeki, Yamashita Satoshi, Yamada Masayoshi, Hashimoto Taiki, Ogawa Reiko, Yoshida Hiroshi, Taniguchi Hirokazu, Kojima Motohiro, Ushijima Toshikazu, Saito Yutaka

Abstract excerpt

BACKGROUND: Traditional serrated adenoma (TSA) is the least common type of colorectal serrated polyp, which exhibits considerable morphological and molecular diversity. METHODS: We examined the spectra of alterations in MAPK and WNT pathway genes and their relationship with clinicopathological features in 128 TSAs. RESULTS: Sequencing analyses identified BRAF V600E, BRAF non-V600E, KRAS, and NRAS mutations in 77,...

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PMID: 32052185
DOI: 10.1007/s00535-020-01673-z

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