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Article

Unique morphologic and genetic characteristics of acute myeloid leukemia with chromothripsis: a clinicopathologic study from a single institution.

Human pathology - 1 Apr 2020

Gao Juehua, Chen Yi-Hua, Mina Alain, Altman Jessica K, Kim Kwang-Youn, Zhang Yanming, Lu Xinyan, Jennings Lawrence, Sukhanova Madina

Abstract excerpt

Chromothripsis is a unique type of genomic instability and is recognized in various cancers. In myeloid neoplasms (MNs), chromothripsis was linked to poor prognosis and specific genetic alterations (complex karyotype, 5q deletions, and loss of TP53). However, the clinicopathologic features of MNs with chromothripsis have not been thoroughly characterized. We identified chromothripsis in 11 cases of MNs (9 acute...

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PMID: 32088209
DOI: 10.1016/j.humpath.2020.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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