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Article

Morphologic findings and mutational profiles of myelodysplastic neoplasms with normal versus abnormal karyotype.

Journal of hematopathology - 20 Feb 2026

Kumar Jyoti, Jensen Alexandria, Lu Rong, Khanna Vishesh, Stehr Henning, Spinner Michael, Fernandez-Pol Sebastian, Greenberg Peter L, Tan Brent

Abstract excerpt

BACKGROUND: Myelodysplastic syndromes are clonal bone marrow failure disorders demonstrating variable degrees of cytopenias, morphologic dysplasia, and risk of progression to acute myeloid leukemia. PURPOSE: We hypothesized that MDS with a normal karyotype (NK) would exhibit a unique mutational or morphologic signature. METHODS: We investigated the morphologic features and genetic profiles of 89 patients with...

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Abnormal Karyotype
Aged
Aged, 80 and over
High-Throughput Nucleotide Sequencing
Karyotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Source

Identifiers

PMID: 41721060
DOI: 10.1007/s12308-026-00686-6

Genes

SF3B1
STAG2
TET2
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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