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Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes

14 Oct 2016

Abstract excerpt

To explore novel genetic abnormalities occurring in myelodysplastic syndromes (MDS) through an integrative study combining array-based comparative genomic hybridization (aCGH) and next-generation sequencing (NGS) in a series of MDS and MDS/myeloproliferative neoplasms (MPN) patients. 301 patients diagnosed with MDS (n = 240) or MDS/MPN (n = 61) were studied at the time of diagnosis. A genome-wide analysis of DNA...

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PMID: 27741277
DOI: 10.1371/journal.pone.0164370

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