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Article

Increased metacyclogenesis of antimony-resistant <i>Leishmania donovani</i> clinical lines

8 Aug 2011

Abstract excerpt

Mathematical models predict that the future of epidemics of drug-resistant pathogens depends in part on the competitive fitness of drug-resistant strains. Considering metacyclogenesis (differentiation process essential for infectivity) as a major contributor to the fitness of Leishmania donovani, we tested its relationship with pentavalent antimony (SbV) resistance in clinical lines. Different methods for the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 21819638
DOI: 10.1017/s0031182011001120

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