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Article

TERT, BRAF, and NRAS Mutational Heterogeneity between Paired Primary and Metastatic Melanoma Tumors.

The Journal of investigative dermatology - 1 Aug 2020

Chang Gregory A, Wiggins Jennifer M, Corless Broderick C, Syeda Mahrukh M, Tadepalli Jyothirmayee S, Blake Shria, Fleming Nathaniel, Darvishian Farbod, Pavlick Anna, Berman Russell, Shapiro Richard, Shao Yongzhao, Karlin-Neumann George, Spittle Cindy, Osman Iman, Polsky David

Abstract excerpt

Mutational heterogeneity can contribute to therapeutic resistance in solid cancers. In melanoma, the frequencies of intertumoral and intratumoral heterogeneity are controversial. We examined mutational heterogeneity within individual patients with melanoma using multiplatform analysis of commonly mutated driver and nonpassenger genes. We analyzed paired primary and metastatic tumors from 60 patients and multiple...

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Identifiers

PMID: 32087194
DOI: 10.1016/j.jid.2020.01.027
PMCID: PMC7387168

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