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Article

Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions.

Cancer research and treatment - 1 Oct 2018

Lee Si-Hyung, Kim Jee Eun, Jang Hong Sun, Park Kyu Hyun, Oh Byung Ho, Shin Sang Joon, Chung Kee Yang, Roh Mi Ryung, Rha Sun Young

Abstract excerpt

PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between primary and metastatic melanoma in Korean melanoma patients, we evaluated several well-known genetic alterations of melanoma. In addition, to elucidate the clinical relevance of each genetic...

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Source

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Identifiers

PMID: 29361821
DOI: 10.4143/crt.2017.535
PMCID: PMC6192908

Genes

BRAF
GNAQ
KIT
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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