Article
Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma.
PloS one - 1 Jan 2012
Yancovitz Molly, Litterman Adam, Yoon Joanne, Ng Elise, Shapiro Richard L, Berman Russell S, Pavlick Anna C, Darvishian Farbod, Christos Paul, Mazumdar Madhu, Osman Iman, Polsky David
Abstract excerpt
The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With the emergence of BRAF(V600E) as a therapeutic target, we investigated intra- and inter-tumor heterogeneity in melanoma using detection of the BRAF(V600E) mutation as a marker of clonality. BRAF...
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