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Article

Varying Mutational Alterations in Multiple Primary Melanomas.

The Journal of molecular diagnostics : JMD - 1 Jan 2016

Egberts Friederike, Bohne Ann-Sophie, Krüger Sandra, Hedderich Jürgen, Rompel Rainer, Haag Jochen, Röcken Christoph, Hauschild Axel

Abstract excerpt

In melanoma, the mitogen-activated protein (MAP) kinase pathway plays a crucial oncogenic role. Recent studies identified additional genetic alterations, eg, TERT-promoter mutations. Up to 8% of melanoma patients present with multiple primary melanomas (MPMs). The pathogenesis is not fully understood, and data on the genetic diversity of MPMs are limited. To identify putative diagnostic and therapeutic...

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Source

Identifiers

PMID: 26607775
DOI: 10.1016/j.jmoldx.2015.07.010

Genes

NRAS
TERT
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Varying Mutational Alterations in Multiple Primary Melanomas.PMID 26607775Read ↗

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MAPK Pathway and TERT Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases.Semantic proximity Read ↗

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