Article
Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.
Acta dermato-venereologica - 23 Jan 2020
Pellegrini Cristina, Cardelli Ludovica, Padova Marina De, Nardo Lucia Di, Ciciarelli Valeria, Rocco Tea, Cipolloni Gianluca, Clementi Marco, Cortellini Alessio, Ventura Alessandra, Leocata Pietro, Fargnoli Maria Concetta
Abstract excerpt
Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary melanomas and 39 related metastases, using molecular analysis and immunohistochemistry. BRAF mutations were identified in 46.7% of primary melanomas and 48.7% of...
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