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Article

ApoE influences regional white-matter axonal density loss in Alzheimer's disease.

Neurobiology of aging - 1 Sept 2017

Slattery Catherine F, Zhang Jiaying, Paterson Ross W, Foulkes Alexander J M, Carton Amelia, Macpherson Kirsty, Mancini Laura, Thomas David L, Modat Marc, Toussaint Nicolas, Cash David M, Thornton John S, Henley Susie M D, Crutch Sebastian J, Alexander Daniel C, Ourselin Sebastien, Fox Nick C, Zhang Hui, Schott Jonathan M

Abstract excerpt

Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI) with tract-based spatial statistics to investigate apolipoprotein (APOE) ε4 modulation of white-matter damage in 37 patients with YOAD (22, 59% APOE ε4 positive) and 23 age-matched controls. Correlation between...

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Identifiers

PMID: 28578156
DOI: 10.1016/j.neurobiolaging.2017.04.021
PMCID: PMC5538347

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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