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Article

Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype.

Glia - 1 Feb 2008

van Rossum Denise, Hilbert Sören, Strassenburg Silke, Hanisch Uwe-Karsten, Brück Wolfgang

Abstract excerpt

Macrophages are key effectors in demyelinating diseases of the central and peripheral nervous system by phagocytosing myelin and releasing immunoregulatory mediators. Here, we report on a distinct, a priori anti-inflammatory reaction of macrophages phagocytosing myelin upon contact with damaged nerve tissue. Macrophages rapidly invaded peripheral (sciatic) and central (optic) nerve tissues in vitro, readily...

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Source

Identifiers

PMID: 18069669
DOI: 10.1002/glia.20611

Genes

CCL11
CCL2
CCL22
CCL3
CCL5
CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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