BDNF Val⁶⁶Met polymorphism to generalized anxiety disorder pathways: Indirect effects via attenuated parasympathetic stress-relaxation reactivity.

doi:10.1037/abn0000507

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Article

BDNF Val⁶⁶Met polymorphism to generalized anxiety disorder pathways: Indirect effects via attenuated parasympathetic stress-relaxation reactivity.

Journal of abnormal psychology - 1 Apr 2020

Chang Hsin-An, Fang Wen-Hui, Liu Yia-Ping, Tzeng Nian-Sheng, Shyu Jia-Fwu, Wan Fang-Jung, Huang San-Yuan, Chang Tieh-Ching, Chang Chuan-Chia

Abstract excerpt

The valine⁶⁶methionine (Val⁶⁶Met) polymorphism (rs6265) of the brain-derived neurotrophic factor (BDNF) gene has been shown to influence autonomic arousal pathways, which in turn predict elevated syndromal anxiety in healthy humans. We examined whether the BDNF variant is associated with an increased risk of generalized anxiety disorder (GAD), one of the most prevalent anxiety disorders, through altering...

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PMID: 32077707
DOI: 10.1037/abn0000507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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