Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction.

doi:10.1016/j.euroneuro.2014.02.005

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Article

Impact of variation in the BDNF gene on social stress sensitivity and the buffering impact of positive emotions: replication and extension of a gene-environment interaction.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2014

van Winkel Mark, Peeters Frenk, van Winkel Ruud, Kenis Gunter, Collip Dina, Geschwind Nicole, Jacobs Nele, Derom Catherine, Thiery Evert, van Os Jim, Myin-Germeys Inez, Wichers Marieke

Abstract excerpt

A previous study reported that social stress sensitivity is moderated by the brain-derived-neurotrophic-factor(Val66Met) (BDNF rs6265) genotype. Additionally, positive emotions partially neutralize this moderating effect. The current study aimed to: (i) replicate in a new independent sample of subjects with residual depressive symptoms the moderating effect of BDNF(Val66Met) genotype on social stress sensitivity,...

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Identifiers

PMID: 24613654
DOI: 10.1016/j.euroneuro.2014.02.005

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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