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Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.

Molecular psychiatry - 1 Jun 2026

Xue Hui, Lei Minghuan, Zhao Qiyu, Zhang Zhihui, Sun Zuhao, Zhang Yujie, Zhai Ying, Xu Jinglei, Wang Ying, An Qi, Cai Wenjie, Jia Linlin, Li Shen, Dai Xi-Jian, Liu Feng

Abstract excerpt

Mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial function and has been associated with several psychiatric disorders. However, the shared genetic architecture between mtDNA-CN and psychiatric conditions remains largely unexplored. Utilizing the largest available genome-wide association study (GWAS) summary statistics from individuals of European ancestry, we systematically investigated the shared...

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Share to DNA Copy Number Variations
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

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Share to Mitochondria

Share to Polymorphism, Single Nucleotide

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PMID: 41634133
DOI: 10.1038/s41380-026-03463-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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