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Article

Effects of ordered mutations on dynamics in signaling networks.

BMC medical genomics - 20 Feb 2020

Mazaya Maulida, Trinh Hung-Cuong, Kwon Yung-Keun

Abstract excerpt

BACKGROUND: Many previous clinical studies have found that accumulated sequential mutations are statistically related to tumorigenesis. However, they are limited in fully elucidating the significance of the ordered-mutation because they did not focus on the network dynamics. Therefore, there is a pressing need to investigate the dynamics characteristics induced by ordered-mutations. METHODS: To quantify the...

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PMID: 32075651
DOI: 10.1186/s12920-019-0651-z
PMCID: PMC7032007

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