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Article

Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Apr 2020

Priyadarshini Medha, Cole Connor, Oroskar Gautham, Ludvik Anton E, Wicksteed Barton, He Congcong, Layden Brian T

Abstract excerpt

The free fatty acid receptor 3 (FFA3) is a nutrient sensor of gut microbiota-generated nutrients, the short-chain fatty acids. Previously, we have shown that FFA3 is expressed in β-cells and inhibits islet insulin secretion ex vivo. Here, we determined the physiological relevance of the above observation by challenging wild-type (WT) and FFA3 knockout (KO) male mice with 1) hyperglycemia and monitoring insulin...

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Source

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Identifiers

PMID: 32073900
DOI: 10.1152/ajpregu.00128.2019
PMCID: PMC7191418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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