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Article

Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy.

Nature communications - 18 Feb 2020

Wang Xue-Jing, Ma Ming-Ming, Zhou Le-Bo, Jiang Xiao-Yi, Hao Miao-Miao, Teng Robert K F, Wu Erxi, Tang Bei-Sha, Li Jia-Yi, Teng Jun-Fang, Ding Xue-Bing

Abstract excerpt

α-Synucleinopathies are characterized by autonomic dysfunction and motor impairments. In the pure autonomic failure (PAF), α-synuclein (α-Syn) pathology is confined within the autonomic nervous system with no motor features, but mouse models recapitulating PAF without motor dysfunction are lacking. Here, we show that in TgM83+/- mice, inoculation of α-Syn preformed fibrils (PFFs) into the stellate and celiac...

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Identifiers

PMID: 32071315
DOI: 10.1038/s41467-019-14189-9
PMCID: PMC7028908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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