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Article

Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype.

PloS one - 1 Jan 2015

Kuzdas-Wood Daniela, Irschick Regina, Theurl Markus, Malsch Philipp, Mair Norbert, Mantinger Christine, Wanschitz Julia, Klimaschewski Lars, Poewe Werner, Stefanova Nadia, Wenning Gregor K

Abstract excerpt

UNLABELLED: Multiple system atrophy (MSA) is a fatal, rapidly progressive neurodegenerative disease with (oligodendro-)glial cytoplasmic α-synuclein (α-syn) inclusions (GCIs). Peripheral neuropathies have been reported in up to 40% of MSA patients, the cause remaining unclear. In a transgenic MSA mouse model featuring GCI-like inclusion pathology based on PLP-promoter driven overexpression of human α-syn in...

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Identifiers

PMID: 26496712
DOI: 10.1371/journal.pone.0136575
PMCID: PMC4619736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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