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Article

Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases.

PLoS biology - 1 Feb 2020

Welsh Robin A, Song Nianbin, Foss Catherine A, Boronina Tatiana, Cole Robert N, Sadegh-Nasseri Scheherazade

Abstract excerpt

DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells. Previous reports have suggested possible links between DO and autoimmunity, Hepatitis C (HCV) infection, and cancer, but the mechanism of how DO contributes to these diseases remains unclear. Here, using a combination of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32069316
DOI: 10.1371/journal.pbio.3000590
PMCID: PMC7028248

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