Article
Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.
Proceedings of the National Academy of Sciences of the United States of America - 25 Feb 2020
Lin Hong, Zhang Xiaozhe, Liu Li, Fu Qiuyu, Zang Chuanlong, Ding Yan, Su Yang, Xu Zhixue, He Sining, Yang Xiaoli, Wei Xiayun, Mao Haibin, Cui Yasong, Wei Yi, Zhou Chuanzheng, Du Lilin, Huang Niu, Zheng Ning, Wang Tao, Rao Feng
Abstract excerpt
The Cullin-RING ligases (CRLs) are the largest family of ubiquitin E3s activated by neddylation and regulated by the deneddylase COP9 signalosome (CSN). The inositol polyphosphate metabolites promote the formation of CRL-CSN complexes, but with unclear mechanism of action. Here, we provide structural and genetic evidence supporting inositol hexakisphosphate (IP6) as a general CSN cofactor recruiting CRLs. We...
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