Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly.

Molecular and cellular biology - 1 Dec 2017

Liu Qingqing, Zhou Yike, Tang Ruiqi, Wang Xuehong, Hu Qiwen, Wang Ying, He Qun

Abstract excerpt

The dynamic SCF (Skp1-cullin1-F-box protein) assembly is controlled by cycles of cullin neddylation/deneddylation based on the deneddylation activity of the COP9 signalosome (CSN) and global sequestration of cullins by CAND1. However, acceptance of this prediction was hampered by the results of recent studies, and the regulatory mechanism and key players remain to be identified. We found that maintaining a proper...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cullin Proteins

Share to Multiprotein Complexes

Share to Neurospora

Share to Phenotype

Share to SKP Cullin F-Box Protein Ligases

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 28923850
DOI: 10.1128/MCB.00109-17
PMCID: PMC5686579

Genes

CAND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly.PMID 28923850Read ↗

F-box-directed CRL complex assembly and regulation by the CSN and CAND1.Semantic proximity Read ↗

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.Semantic proximity Read ↗

DEN1 deneddylates non-cullin proteins in vivo.Semantic proximity Read ↗

Deneddylase 1 regulates deneddylase activity of the Cop9 signalosome in Drosophila melanogaster.Semantic proximity Read ↗

CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome.Semantic proximity Read ↗

The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.Semantic proximity Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

The C-terminal tail of CSNAP attenuates the CSN complex.Semantic proximity Read ↗

The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.Semantic proximity Read ↗

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.Semantic proximity Read ↗

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Semantic proximity Read ↗

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.