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PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

10 Feb 2020

Abstract excerpt

Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors used to treat BRCA1/2-deficient cancers. However, upon chronic treatment of BRCA1-mutant cells with PARP inhibitors, resistant clones can arise via several mechanisms, including loss of 53BP1 or its downstream...

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PMID: 32041954
DOI: 10.1038/s41467-020-14563-y

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