Article
Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.
Molecular cell - 1 Feb 2001
Davies A A, Masson J Y, McIlwraith M J, Stasiak A Z, Stasiak A, Venkitaraman A R, West S C
Abstract excerpt
Individuals carrying BRCA2 mutations are predisposed to breast and ovarian cancers. Here, we show that BRCA2 plays a dual role in regulating the actions of RAD51, a protein essential for homologous recombination and DNA repair. First, interactions between RAD51 and the BRC3 or BRC4 regions of BRCA2 block nucleoprotein filament formation by RAD51. Alterations to the BRC3 region that mimic cancer-associated BRCA2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.