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Filling Adeno-Associated Virus Capsids: Estimating Success by Cryo-Electron Microscopy

18 Sept 2019

Abstract excerpt

Adeno-associated viruses (AAVs) have been employed successfully as gene therapy vectors in treating various genetic diseases for almost two decades. However, transgene packaging is usually imperfect, and developing a rapid and accurate method for measuring the proportion of DNA encapsidation is an important step for improving the downstream process of large scale vector production. In this study, we used...

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PMID: 31530236
DOI: 10.1089/hum.2019.041

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