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An Easy and Efficient Strategy for the Enhancement of Epothilone Production Mediated by TALE-TF and CRISPR/dcas9 Systems in Sorangium cellulosum

26 Nov 2019

Abstract excerpt

Epothilones are a kind of macrolides with strong cytotoxicity towards cancer cells and relatively lower side effects compared with taxol. Epothilone B derivate ixabepilone has been used for the clinical treatment of advanced breast cancer. However, the low yield of epothilones and the difficulty in the genetic manipulation of S. cellulosum limited their wider application. Transcription activator-like...

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PMID: 32039165
DOI: 10.3389/fbioe.2019.00334

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An Easy and Efficient Strategy for the Enhancement of Epothilone Production Mediated by TALE-TF and CRISPR/dcas9 Systems in Sorangium cellulosumPMID 32039165Read ↗

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