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Article

Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium.

Journal of industrial microbiology & biotechnology - 1 Sept 2007

Gong Guo-li, Sun Xin, Liu Xin-li, Hu Wei, Cao Wen-rui, Liu Hong, Liu Wei-feng, Li Yue-zhong

Abstract excerpt

The epothilones are highly promising prospective anticancer agents that are produced by the myxobacterium Sorangium cellulosum. We mutated the epothilone producing S. cellulosum strain So0157-2 to improve the production of epothilones. For evaluation in high-throughput of a large number of mutants, we developed a simple microtiter method for primary screening. Using the classical UV-mutation method plus selection...

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PMID: 17647035
DOI: 10.1007/s10295-007-0236-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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