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Article

Preparation and separation of epothilones with anticancer activity.

Chemical biology & drug design - 1 Aug 2020

Long Rong, Yang Wenjian, Huang Gangliang

Abstract excerpt

Epothilone is a kind of macrolide compound, which has anticancer activity and strong inhibitory effect on breast cancer and rectal cancer cells. Herein, the chemical and biological synthesis of epothilones and how to improve fermentation yield and separation methods were summarized and discussed.

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PMID: 32220102
DOI: 10.1111/cbdd.13687

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