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Article

Genetic variation present in the CYP3A4 gene in Ni-Vanuatu and Kenyan populations in malaria endemicity.

Drug metabolism and pharmacokinetics - 1 Aug 2024

Musyoka Kelvin, Chan Chim W, Gutiérrez Rico Evelyn Marie, Omondi Protus, Kijogi Caroline, Okai Takatsugu, Kongere James, Ngara Mtakai, Kagaya Wataru, Kanoi Bernard N, Hiratsuka Masahiro, Kido Yasutoshi, Gitaka Jesse, Kaneko Akira

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4) enzyme is involved in the metabolism of about 30 % of clinically used drugs, including the antimalarials artemether and lumefantrine. CYP3A4 polymorphisms yield enzymatic variants that contribute to inter-individual variation in drug metabolism. Here, we examined CYP3A4 polymorphisms in populations from malaria-endemic islands in Lake Victoria, Kenya, and Vanuatu, to expand on the...

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PMID: 39079373
DOI: 10.1016/j.dmpk.2024.101029

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