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Article

Feasibility of Combined Detection of Gene Mutations and Fusion Transcripts in Bone Marrow Trephines from Leukemic Neoplasms.

The Journal of molecular diagnostics : JMD - 1 Apr 2020

Bartels Stephan, Hasemeier Britta, Vogtmann Julia, Schipper Elisa, Büsche Guntram, Schlue Jerome, Kreipe Hans, Lehmann Ulrich

Abstract excerpt

Chromosomal translocations resulting in fusion genes represent important oncogenic drivers and potential therapeutic targets in rare leukemia subtypes. Formalin-fixed, paraffin-embedded trephines are frequently used in hematologic diagnostic tests and provide relevant access to leukemic cells for further studies, for example, phenotyping in bone marrow fibrosis. However, high-throughput molecular analysis of...

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Identifiers

PMID: 32036087
DOI: 10.1016/j.jmoldx.2020.01.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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