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Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics

29 Jul 2020

Abstract excerpt

BACKGROUND: We have evaluated an NGS-based method to detect recurrent gene fusions of diagnostic and prognostic importance in hematological malignancies. Our goal was to achieve a highly specific assay with a simple workflow, short turnaround time and low cost. METHOD: The assay uses a commercially available anchored multiplex PCR panel for target enrichment and library preparation, followed by sequencing using a...

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PMID: 32727569
DOI: 10.1186/s12920-020-00739-4

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