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FuseFISH: Robust Detection of Transcribed Gene Fusions in Single Cells

1 Jan 2014

Abstract excerpt

Transcribed gene fusions are key biomarkers in many hematologic and solid tumors, often representing the primary oncogenic driver mutation. Here, we report an experimental and computational pipeline for detecting fusion transcripts using single-molecule RNA FISH and unbiased correlation analysis (FuseFISH). We constructed a genome-wide database of optimal oligonucleotide sequences, enabling quick design of...

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PMID: 24373969
DOI: 10.1016/j.celrep.2013.12.002

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