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Article

Applicability of next-generation sequencing to decalcified formalin-fixed and paraffin-embedded chronic myelomonocytic leukaemia samples.

International journal of clinical and experimental pathology - 1 Jan 2014

Bernard Veronica, Gebauer Niklas, Dinh Thomas, Stegemann Judith, Feller Alfred C, Merz Hartmut

Abstract excerpt

Decalcified formalin-fixed and paraffin-embedded (dFFPE) bone marrow trephines remain the primary source of gDNA in hematopathological diagnostics. Here, we investigated the applicability of next-generation sequencing (NGS) to dFFPE samples. Chronic myelomonocytic leukaemia (CMML) is a haematopoietic stem cell malignancy delineated by genetic heterogeneity. Recently characteristic mutations have been identified...

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Share to Bone Marrow Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Chronic

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Share to Proto-Oncogene Proteins c-cbl

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Source

Open in PubMed Open full text

Identifiers

PMID: 24817963
PMCID: PMC4014247

Genes

CBL
KRAS
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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