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NARASIMHA: Novel Assay based on Targeted RNA Sequencing to Identify ChiMeric Gene Fusions in Hematological Malignancies

5 May 2020

Abstract excerpt

Chimeric gene fusions (CGF) are the hallmark of several haematological malignancies. Their exact characterization is critical for accurate diagnosis, administering targeted therapy, as well as effective post therapeutic monitoring. In that context, commonly used molecular techniques such as fluorescent in situ hybridization (FISH) are limited by low sensitivity (~5–10%), and an inherent inability to provide...

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PMID: 32372024
DOI: 10.1038/s41408-020-0313-6

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